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Hand SCC In Situ

November 13, 2017

HISTORY 68-year-old woman presents with a many month history of squamous cell in situ of left hand. This large 2.5 cm lesion on the hand poses a unique challenge to ensuring hand function post-operatively. Treatment options include C&D (curettage and desiccation), curettage only with post-treatment imiquimod, Mohs excision with a skin graft closure, or superficial…

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CONJUCTIVAL SQUAMOUS CELL CARCINOMA

March 10, 2017

  HISTORY 69 year old man presented in August 2016 for a large papillomatous lesion of the left inferior cornea. Patient has a history of left lower eyelid basal cell carcinoma that was treated in 2014. The area of corneal carcinoma was initially thought to be exposure keratitis.       DISCUSSION The patient is…

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DNA Molecular Testing and Personalized Medicine – Part 2

January 3, 2013

Another genetic molecular technology that has evolved tremendously is real time polymerase chain reaction (PCR). When accompanied by reverse transcription prior to PCR (RT-PCR), it has also allowed rapid multiple gene analysis useful for cancer staging such as OncotypeDx. This platform analyzes RNA for 21 genes with RT-PCR to stratify breast cancer patients according to…

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Squamous Cell Carcinoma Lower Lip

March 18, 2011

A man in his thirties with lifelong h/o severe actinic cheilitis of left lower lip. Recurrent flare-ups of cheilitis have been treated as recurrent herpetic infection. Recently he has experienced worsening of cheilitis and appearance of the lesion. Biopsy found squamous cell carcinoma with perineural invasion. Lip invasion was histologically measured to be > 2mm…

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STUMP and MelTUMP

October 31, 2012

Ambiguous melanocytic lesions – those with histopathologic findings without a diagnostic consensus – are divided into thin and thick tumors. Thin lesions appear as dysplastic nevi and have a potential of being part of melanoma in situ or superficial spreading melanoma. We have explored diagnostic and therapeutic considerations of the thin lesions in a previous…

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INVASIVE BOWEN’S CARCINOMA OF CHEEK

April 3, 2017

HISTORY 79 year old woman presented with a 3 month history of right angle of jaw mass hardening over time. A biopsy of a separate lesion of the right central cheek on 2/21/17 showed papillated Bowen’s Disease. The jaw mass was biopsied on 2/24/17 and revealed invasive Bowen’s carcinoma – squamous cell carcinoma. DISCUSSION This…

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