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Aggressive Forehead SCC


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78-year-old man with a recurrence of squamous cell carcinoma of forehead following surgery and radiation. Resection was performed in 4/2016 and radiation followed. Lesion recurred within 1 week of completion of radiation within radiation field. Originally presented with squamous cell carcinoma with perineural invasion and 4.5mm depth of invasion, arising from squamous cell carcinoma in situ.

Patient was treated with infusion immunotherapy, which has been unsuccessful. Chemotherapy was started in January 2017 and discontinued in May 2017. Patient has a history of Non-Hodgkin’s lymphoma, and multiple skin cancers. His brother died of an aggressive metastatic squamous cell carcinoma of the skin.