Posts Tagged ‘Erivedge’
FIELD CANCERIZATION WITH BASAL CELL CARCINOMA
2012 Radiation Simulation Persistent cheek recurrence of BCC at edge of flap recent CT showing resected right temporal bone with overlying flap and evidence of deep tumor HISTORY This 69-year-old man presented with greater than 25-year history of multiple basal cell carcinomas of the face and neck. His most problematic cancer has been in the…
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LOWER LID CARCINOMA
HISTORY This 84 year old man was initially seen with a large left facial lesion. Biopsy diagnosed basal cell carcinoma in 3 locations of biopsy. The patient was reluctant to undergo a surgical excision and reconstruction. Vismodegib (Erivedge) was used as primary treatment. Patient completed a 4 month course of 150mg daily vismodegib dose. He…
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MEDIAL CANTHUS BASAL CELL CARCINOMA FOLLOW UP
HISTORY 91 year old man presented with a recurrent right medial canthus BCC that was previously treated with 45 days of radiation (SRT at Hoag Hospital). Biopsy showed infiltrative sclerosing basal cell carcinoma with focal perineural invasion. MRI in December of 2016 showed the mass was fixed on the lamina papyracea adjacent to the medial…
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MAPPING OF BCC WITH CONFOCAL MICROSCOPY
HISTORY 63 year old woman diagnosed with recurrence of BCC of left upper lip in 2015 after treatment of Efudex and a surgical excision in 2005. Patient had 3 separate BCC locations in left upper lip. Due to the size and multifocality of the lesion, patient was treated with Erivedge for 7…
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Smoothened and Patched and Sonic Hedgehogs – From Cyclopic Sheep to Targeted Basal Cell Carcinoma Treatment
What does Frizzled, Frazzled, Dishevelled, and Smoothened have to do with the Sonic Hedgehog? These are some of the humorously named genes in Drosophila fruit flies that also happened to be expressed in humans. Besides adding character to the genes, these names occasionally reflect the traits they describe. Hedgehog (Hh) gene is part of the…
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