Posts Tagged ‘5-fluorouracil’
Augmenting Efficacy of Topical 5-FU for Actinic Keratoses and Skin Cancer
Diffuse actinic sun damage can present a challenge for both patients and providers. First line treatment options include topical 5-fluorouracil (5-FU) cream or photodynamic therapy (PDT). Topical 5-FU cream is applied to the affected area for 2-3 weeks creating inflammation, redness, and crusting as the body eliminates the actinic damage. Alternatively, topical levulan is applied…
Read More
A Simple Cream for Cancer with Not Always Simple Consequences
HISTORY A 62-year-old woman presents with multiple hypopigmented areas of previous skin cancer treatment with imiquimod. DISCUSSION Some patients find themselves with a large number of skin cancers and pre-cancerous lesions. While surgical excision is recommended for certain types of skin cancer, pre-cancers and superficial skin cancers can often be treated in other ways. These…
Read More
Multiple Cutaneous Carcinomas in Organ Transplant Recipients
HISTORY A 73-year-old kidney transplant recipient presented with multiple carcinomas including SCC, SCC in situ, and BCC of the face and scalp. DISCUSSION Organ transplant recipients can suffer from multiple cutaneous carcinomas. Some lesions can have a high risk of metastases, but most occur in multitudes in areas of extensive sun exposure. At SCARS Center,…
Read More
Intralesional 5-fluorouracil for Cutaneous BCC and SCC
HISTORY An 86-year-old man on hemodialysis with multiple medical problems and on warfarin presented with two carcinomas of the nasal tip: BCC of the left nasal tip and SCC of the right nasal tip. The ulceration of the right SCC exposed the alar cartilage. Patient completed six (6) 5-fluorouracil injections over a 5-week period. Complete…
Read More
Recurrent Bowen’s Disease of Temple
HISTORY 63-year-old man presents with 9-month history of Bowen’s disease of right anterior and posterior sideburn biopsied on 08-20-18. History of previous Mohs excision of Bowen’s disease of the same area in February 2016. Patient has a history of multiple basal cell carcinomas, squamous cell carcinomas, and melanoma. DISCUSSION Management of this lesion is best…
Read More
Forehead SCC with Perineural Invasion
HISTORY 83-year-old man presented in 02/2017 with a 3-year history of a forehead and temple SCC. The cancer was initially treated with cryoablation and 5-FU. Excision on 9/2/16 was performed with residual circumferential margins. Histology found poorly differentiated sclerosing squamous cell carcinoma, with perineural invasion of 0.1 mm nerves. Wide local resection with radial…
Read More
Twice Recurrent Upper Eyelid SCC
HISTORY 53-year-old man presents with a recurrent upper eyelid induration and margin retraction for 3 months. Punch biopsy confirmed squamous cell carcinoma (SCC) recurrence. The first SCC excision with frozen sections and reconstruction was done 12-17-13 elsewhere. Subsequently, the eyelid was treated with LN2 in 2014 for surface AK. Carcinoma recurred at the lid margin…
Read More
LOWER LIP ATYPIA AT MARGINS OF SQUAMOUS CELL CARCINOMA
HISTORY 89-year-old man presents with several month history of lesion on bottom lip. A biopsy was taken on 8-9-17 and showed severe squamous atypia without ruling out deeper SCC. Excision of lesion done 9-6-17 showed invasive squamous cell carcinoma with foci of moderate squamous dysplasia from 9 to 3 o’clock. Patient has history of…
Read More
Topical 5-fluorouracil and Imiquimod Efficacy in Basal and Squamous Cell Carcinomas
HISTORY 65-year-old woman presented in January 2017 with a nasal dorsum squamous cell carcinoma in situ. The nasal lesion was treated with 6 weeks of topical 5-fluorouracil with a robust inflammatory response. A separate chin basal cell carcinoma was simultaneously treated with 6 weeks of imiquimod prescribed in February, while still undergoing 5-fluorouracil on the…
Read More
CONJUCTIVAL SQUAMOUS CELL CARCINOMA
HISTORY 69 year old man presented in August 2016 for a large papillomatous lesion of the left inferior cornea. Patient has a history of left lower eyelid basal cell carcinoma that was treated in 2014. The area of corneal carcinoma was initially thought to be exposure keratitis. DISCUSSION The patient is a 69-year-old organ transplant…
Read More